The 2nd International Conference on Main Group Synthesis and Catalysis (ICMGSC-2025) will be jointly organized by the Indian Institute of Science Education and Research (IISER Thiruvananthapuram and the Royal Society of Chemistry from 13th to 16th February 2025. It aims to bring together practicing main group chemists around the globe fostering discussions on topical areas of interest in the field. The conference will feature 40 talks, poster presentations, and networking opportunities. This second edition is organised at the backdrop of the huge success of the first edition that immensely benefited the main group chemistry community.